Analytical Data
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Gene name
NKX6-2
- Application
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Alternative Names
GTX; Homeobox protein NK-6 homolog B; Homeobox protein Nkx 6.2; Homeobox protein Nkx-6.2; MGC126684; NK6 homeobox 2; NK6 transcription factor related. locus 2; NKX6-2; NKX6.2; NKX62_HUMAN; NKX6B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C056
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Expression Region
1-277 aa
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AA Sequence
MDTNRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KAPALGGLGA QLPLGTPHGI SDILGRPVGA AGGGLLGGLP RLNGLASSAG VYFGPAAAVA RGYPKPLAEL PGRPPIFWPG VVQGAPWRDP RLAGPAPAGG VLDKDGKKKH SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR TKWRKRHAVE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK ITRLLKKHKP SNLALVSPCG GGAGDAL
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Molecular Weight
29.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NKX6-2 is a member of the NKX family of homeodomain transcription factors, crucial for the development of various tissues, particularly in the pancreas and the central nervous system. Recent research has highlighted its role in regulating gene expression during embryonic development and the differentiation of stem cells. The study of NKX6-2 is particularly significant in the context of diabetes research, as it is implicated in the specification and maintenance of pancreatic beta cells, which are responsible for insulin production. Dysfunction or loss of NKX6-2 expression has been associated with impaired pancreatic function and the onset of diabetes. Furthermore, NKX6-2 has been identified as a potential therapeutic target for regenerative medicine aimed at repairing damaged pancreatic tissues. The recombinant protein form of NKX6-2 allows for in-depth studies on its biochemical properties, interaction with other proteins, and its functional role in cellular processes. Understanding the mechanisms by which NKX6-2 operates could open new avenues for therapies aimed at restoring insulin production in diabetic patients, making it a pivotal focus for both developmental biology and clinical applications.
