Analytical Data
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Gene name
RPS24
- Application
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Alternative Names
RPS24;Small ribosomal subunit Protein eS24
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62847-2
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Expression Region
1-130aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMNDTVTI RTRKFMTNRL LQRKQMVIDV LHPGKATVPK TEIREKLAKM YKTTPDVIFV FGFRTHFGGG KTTGFGMIYD SLDYAKKNEP KHRLARHGLY EKKKTSRKQR KERKNRMKKV RGTAKANVGA GKK
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPS24, a ribosomal protein S24, is a vital component of the 40S ribosomal subunit, playing a crucial role in ribosome biogenesis and protein synthesis. Recent studies have highlighted its significance in cellular processes, including the regulation of translation and cell proliferation. Mutations in the RPS24 gene are associated with Diamond-Blackfan anemia (DBA), a rare genetic disorder characterized by macrocytic anemia and a predisposition to cancer. The investigation of RPS24 recombinant proteins is essential for understanding the molecular mechanisms underlying these conditions and may provide insight into potential therapeutic targets. Furthermore, RPS24 has been observed to be involved in various signaling pathways, suggesting that its functional assays could illuminate new facets of protein synthesis regulation in response to cellular stressors. By producing recombinant RPS24 proteins in model organisms or expression systems, researchers aim to elucidate its structural properties, functional interactions, and role in disease progression. This research not only enhances the understanding of ribosomal function and assembly but also contributes to the broader field of translational medicine, with implications for the development of targeted treatments for DBA and other associated disorders. The ongoing exploration of RPS24 and its recombinant forms could lead to groundbreaking advancements in the diagnosis and management of ribosomopathies, underscoring the importance of this ribosomal protein in maintaining cellular and organismal health.
