Analytical Data
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基因名
UPK3B
- Application
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别名
UPK3B；Uroplakin-3b
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BT76
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表达区间
1-320aa
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氨基酸序列
MGLPWGQPHLGLQMLLLALNCLRPSLSLGEWGSWMDASSQTQGAGGPAGVIGPWAPAPLRLGEAAPGTPTPVSVAHLLSPVATELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLASASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLPLSPDQLPCGDPMAGSGGAPVLRVGHDHGCHQQPFCNAPLPGPGPYREDPRIHRHLARAAKWQHDRHYLHPLFSGRPPTLGLLGSLYHALLQPVVAGGGPGAAADRLLHGQALHDPPHPTQRGRHTAGGLQAWPGPPPQPQPLAWPLCMGLGEMGRWE
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分子量
33.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UPK3B, a member of the uroplakin family, plays a crucial role in the formation and function of the uroepithelium, the protective lining of the urinary tract. This protein is a key component of the urothelial plaque, essential for maintaining the barrier function against environmental factors such as urine flow and pathogens. Recent studies have indicated that UPK3B might be implicated in various urological diseases, including bladder cancer and infections. The need for recombinant UPK3B protein has arisen for several reasons: to better understand its molecular mechanisms, explore its role in disease pathogenesis, and evaluate its potential as a diagnostic or therapeutic target. The production of recombinant UPK3B allows for in-depth functional studies, including protein interaction assays and structure-function relationships, which are pivotal in elucidating its biological significance. Moreover, as UPK3B exhibits distinct expression patterns in healthy versus diseased tissues, recombinant forms of this protein could serve as biomarkers or therapeutic agents, emphasizing the importance of characterizing its properties in a controlled laboratory setting. By delving into the structure and function of UPK3B through recombinant protein techniques, researchers aim to bridge gaps in knowledge regarding its biological significance and potential clinical applications, thereby contributing to advancements in urological health research.
