Analytical Data
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Gene name
RPS19
- Application
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Alternative Names
RPS19;Small ribosomal subunit Protein eS19
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P39019
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Expression Region
2-145aa
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AA Sequence
PGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RPS19, a gene located on chromosome 19, encodes a ribosomal protein that is an essential component of the small ribosomal subunit. Mutations in the RPS19 gene are primarily associated with Diamond-Blackfan Anemia (DBA), a rare inherited blood disorder characterized by insufficient red blood cell production and various physical malformations. Research into RPS19 and its role in ribosome biogenesis and protein synthesis has gained significant attention due to its implications in both disease pathology and fundamental cellular processes. The study of recombinant RPS19 protein provides crucial insights into its structural and functional characteristics, allowing for the exploration of the molecular mechanisms underlying DBA. Additionally, recombinant RPS19 can be employed in therapeutic advancements and the development of potential gene therapies aimed at correcting the underlying genetic defects. Understanding RPS19’s function is also pivotal for elucidating the broader implications of ribosomal protein mutations in various forms of anemia and conditions such as cancer, where ribosome biogenesis is often dysregulated. Overall, ongoing research on RPS19 recombinant protein holds promise for enhancing our knowledge of ribosomal function in health and disease, paving the way for innovative treatment strategies for DBA and related disorders.
