Analytical Data
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Gene name
KLHDC2
- Application
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Alternative Names
KLHDC2；HCA33；Kelch domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2U9
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Expression Region
1-406aa
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AA Sequence
MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS
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Molecular Weight
46.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLHDC2, or Kelch domain-containing protein 2, is a member of the Kelch-like protein family known for its role in various cellular processes, including signal transduction and protein ubiquitination. Research has highlighted KLHDC2's potential involvement in critical biological functions, such as developmental regulation and immune response modulation. Emerging studies suggest that this protein may play a significant role in cancer biology, particularly in tumor progression and metastasis, indicating its potential as a therapeutic target. Given the complexities of its interactions and functionalities, scientists have focused on elucidating the structural characteristics and mechanisms of KLHDC2 through recombinant protein studies. By producing KLHDC2 in a laboratory setting, researchers aim to better understand its biochemical properties and interactions with other cellular components, thereby laying the groundwork for potential applications in disease treatment and biomarker development. These investigations not only enhance our knowledge of KLHDC2's biological roles but could pave the way for innovative strategies in clinical interventions. As such, KLHDC2 represents a promising avenue for further research in protein biology and its implications in health and disease.
