Analytical Data
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Gene name
NFKBIZ
- Application
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Alternative Names
FLJ30225; FLJ34463; I-kappa-B-zeta; Ikappa B zeta; IkappaB zeta; IkappaBzeta; IkB-zeta; IKBZ; IKBZ_HUMAN; IKBzeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; MAIL protein; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYH8
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Expression Region
1-718 aa
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AA Sequence
MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL NPVVVPQSSP AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES ENIANPMQTS SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP FSNMGNPMNT TQLGKSLFQW QVEQEESKLA NISQDQFLSK DADGDTFLHI AVAQGRRALS YVLARKMNAL HMLDIKEHNG QSAFQVAVAA NQHLIVQDLV NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN QFVDLEATNY DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN TALHVAASLQ YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE QIRRILKGKS IQQRAPPY
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Molecular Weight
78.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NFKBIZ, also known as NF-kappa-B inhibitor zeta, is a protein that plays a critical role in the regulation of the NF-kappa-B signaling pathway, which is essential for various cellular processes, including immune responses, inflammation, and cell survival. This protein has garnered significant attention in recent years due to its dual role as both an inhibitor and a modulator of NF-kappa-B activity. Research has shown that NFKBIZ can regulate the expression of target genes involved in inflammatory responses, making it a potential therapeutic target for various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the structure and function of NFKBIZ, including its interaction with other signaling molecules and transcription factors, is crucial for elucidating its role in these pathological processes. Furthermore, the generation of recombinant NFKBIZ protein provides valuable tools for in-depth studies, allowing scientists to investigate its functional mechanisms in a controlled environment. Recent advances in protein engineering and expression systems have facilitated the production of high-purity, biologically active NFKBIZ, paving the way for innovative experimental approaches that could lead to novel therapeutic strategies aimed at modulating NF-kappa-B signaling for improved disease management. This research could ultimately contribute to the development of new pharmacological interventions that target NFKBIZ and its associated pathways, enhancing our understanding of immune regulation and inflammation at both cellular and systemic levels.
