Analytical Data
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基因名
NFE2
- Application
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别名
erythroid-derived 2 45 kDa subunit; Leucine zipper protein NF-E2; Leucine zipper protein NFE2; NF E2; nfe2; NFE2_HUMAN; Nuclear factor (erythroid derived 2); 45kDa; nuclear factor (erythroid-derived 2); 45kD; Nuclear factor; nuclear factor; erythroid 2; Nuclear factor; erythroid derived 2 45 kDa subunit; p45; p45 NF-E2; p45 NFE2; Transcription factor NF-E2 45 kDa subunit; Transcription factor NFE2 45 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16621
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表达区间
1-373 aa
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氨基酸序列
MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP QAPAPYLGPP PPTTYCPCSI HPDSGFPLPP PPYELPASTS HVPDPPYSYG NMAIPVSKPL SLSGLLSEPL QDPLALLDIG LPAGPPKPQE DPESDSGLSL NYSDAESLEL EGTEAGRRRS EYVEMYPVEY PYSLMPNSLA HSNYTLPAAE TPLALEPSSG PVRAKPTARG EAGSRDERRA LAMKIPFPTD KIVNLPVDDF NELLARYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER LTNERERLLR ARGEADRTLE VMRQQLTELY RDIFQHLRDE SGNSYSPEEY ALQQAADGTI FLVPRGTKME ATD
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分子量
41.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NFE2 (Nuclear Factor Erythroid 2) is a crucial transcription factor involved in various biological processes, particularly in the regulation of erythropoiesis and antioxidant defense mechanisms. Its role in hematopoietic development has garnered attention due to its involvement in the differentiation of erythroid progenitors, contributing to the synthesis of hemoglobin. Recent studies have highlighted the significance of NFE2 in cellular responses to oxidative stress, making it essential for maintaining redox homeostasis. Furthermore, aberrations in NFE2 function are linked to disorders such as anemia and certain cancers, prompting researchers to explore its potential as a therapeutic target. The recombinant NFE2 protein has become a valuable tool for understanding its molecular mechanisms, facilitating investigations into its interactions with DNA and other proteins. By utilizing recombinant technology, scientists can produce NFE2 in a controlled environment, allowing them to analyze its structural properties and functional domains. This research not only enhances our comprehension of NFE2's role in cellular physiology but also paves the way for the development of novel interventions against hematological diseases and oxidative stress-related conditions. Overall, the study of recombinant NFE2 protein is instrumental in unraveling its complex biological functions and therapeutic implications.
