Analytical Data
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Gene name
NFATC2IP
- Application
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Alternative Names
45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein. 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells. cytoplasmic 2-interacting protein; nuclear factor of activated T-cells. cytoplasmic. calcineurin-dependent 2 interacting protein; RAD60
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NCF5
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Expression Region
1-419 aa
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AA Sequence
MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL VTDSDEEILE VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA GPPREPVRRR RRLVLDPGEA PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG DEEEAELADS SGLYHEGSPS PGSPWKTKLR TKDKEEKKKT EFLDLDNSPL SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG QEQQGQEDEV VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL RVQGKEKHQT LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG RELPADLGME SGDLIEVWG
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Molecular Weight
45.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NFATC2IP, also known as NFATc2-interacting protein, has gained significant attention in recent years due to its essential role in regulating immune responses, particularly in T-cell activation and differentiation. Its involvement in various physiological processes makes NFATC2IP a key player in both innate and adaptive immunity. Research has indicated that NFATC2IP functions as a negative regulator of NFAT (nuclear factor of activated T-cells) signaling pathways, which are crucial for the expression of cytokines and proliferation of T-cells. Dysregulation of NFATC2IP has been implicated in numerous autoimmune diseases and cancers, highlighting its potential as a therapeutic target. Furthermore, studies have demonstrated that NFATC2IP interacts with several signaling molecules and transcription factors, contributing to the complexity of immune cell signaling networks. The production of recombinant NFATC2IP protein allows for detailed mechanistic studies, as well as the assessment of its functions and interactions within cellular contexts, providing valuable insights into its role in immune regulation. Understanding the structure and function of NFATC2IP might pave the way for novel approaches in treating immune-related disorders and enhancing vaccine efficacy. Thus, ongoing research into NFATC2IP serves as a promising frontier in immunology, potentially leading to breakthroughs in immune modulation and therapeutic development.
