Analytical Data
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Gene name
MICAL2
- Application
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Alternative Names
MICAL2；KIAA0750；MICAL2PV1；MICAL2PV2；[F-actin]-monooxygenase MICAL2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94851
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Expression Region
1-495aa
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AA Sequence
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFY SKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLR TAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFC AGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGW RAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFI NRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFV MTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQ LPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSL LEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEH
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MICAL2, or MICAL-like protein 2, is a member of the MICAL family of proteins that play pivotal roles in various cellular processes, including actin dynamics, cell signaling, and neurogenesis. The study of MICAL2 has gained traction due to its emerging significance in understanding neurodevelopmental disorders, cancer metastasis, and cellular response to oxidative stress. These proteins contain an FAD-binding and a calmodulin-binding domain, which are crucial for their enzymatic activity and modulation of intracellular pathways. MICAL2 has been implicated in the regulation of actin filaments, influencing cell shape and motility, crucial for processes such as neuronal growth cone dynamics. Investigating the recombinant expression of MICAL2 facilitates the elucidation of its structure-function relationships, enabling researchers to dissect its role in various biological contexts. Furthermore, understanding the molecular mechanisms through which MICAL2 operates could provide insights into therapeutic targets for conditions associated with its dysregulation. Recombination techniques also allow for the investigation of potential interaction partners and post-translational modifications, which are essential for its activity and function. This ongoing research enhances our comprehension of MICAL2's participation in fundamental cellular processes, positioning it as a significant focus in cell biology, developmental neuroscience, and cancer research.
