Analytical Data
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基因名
MICAL2
- Application
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别名
MICAL2；KIAA0750；MICAL2PV1；MICAL2PV2；[F-actin]-monooxygenase MICAL2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94851
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表达区间
1-495aa
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氨基酸序列
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFY SKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLR TAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFC AGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGW RAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFI NRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFV MTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQ LPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSL LEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEH
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分子量
59 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MICAL2, or MICAL-like protein 2, is a member of the MICAL family of proteins that play pivotal roles in various cellular processes, including actin dynamics, cell signaling, and neurogenesis. The study of MICAL2 has gained traction due to its emerging significance in understanding neurodevelopmental disorders, cancer metastasis, and cellular response to oxidative stress. These proteins contain an FAD-binding and a calmodulin-binding domain, which are crucial for their enzymatic activity and modulation of intracellular pathways. MICAL2 has been implicated in the regulation of actin filaments, influencing cell shape and motility, crucial for processes such as neuronal growth cone dynamics. Investigating the recombinant expression of MICAL2 facilitates the elucidation of its structure-function relationships, enabling researchers to dissect its role in various biological contexts. Furthermore, understanding the molecular mechanisms through which MICAL2 operates could provide insights into therapeutic targets for conditions associated with its dysregulation. Recombination techniques also allow for the investigation of potential interaction partners and post-translational modifications, which are essential for its activity and function. This ongoing research enhances our comprehension of MICAL2's participation in fundamental cellular processes, positioning it as a significant focus in cell biology, developmental neuroscience, and cancer research.
