Analytical Data
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Gene name
CES3
- Application
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Alternative Names
CES3；Carboxylesterase 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UWW8
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Expression Region
27-571aa
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AA Sequence
TGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL
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Molecular Weight
66.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The CES3 protein, a member of the carboxylesterase family, has gained significant attention in biochemical and pharmacological research due to its crucial roles in drug metabolism and environmental detoxification. As a serine hydrolase, CES3 is involved in the hydrolysis of various ester and amide bonds, making it pivotal in the biotransformation of esters and prodrugs into their active forms. Research has revealed that CES3 exhibits substrate specificity and can influence the pharmacokinetics of numerous clinically relevant drugs, including therapeutic agents and xenobiotics. Additionally, variations in CES3 expression levels across different tissues and among individuals contribute to interindividual differences in drug responses and toxicity. Studies have also suggested that CES3 plays a role in certain metabolic disorders and diseases, underscoring its potential as a biomarker for pharmacogenetic studies. Given the increasing prevalence of drug resistance and the need for personalized medicine, understanding the structure, function, and regulation of CES3 becomes vital. Ongoing research aims to elucidate its catalytic mechanisms, identify novel substrates, and explore the implications of CES3 genetic variations on drug therapy outcomes, paving the way for enhanced therapeutic strategies tailored to individual metabolic profiles.
