Analytical Data
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Gene name
NDUFAB1
- Application
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Alternative Names
ACP; ACPM_HUMAN; Acyl carrier protein; Acyl carrier protein mitochondrial; CI SDAP; CI-SDAP; FASN 2A; FASN2A; MGC65095; Mitochondrial acyl carrier protein; mitochondrial; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1; NADH ubiquinone oxidoreductase 9.6 kDa subunit; NADH ubiquinone oxidoreductase SDAP subunit; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; NDUFAB 1; ndufab1; SDAP
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14561
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Expression Region
69-156 aa
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AA Sequence
SD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD KKDVYE
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Molecular Weight
17.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDUFAB1 (NADH:ubiquinone oxidoreductase complex assembly factor 1) is a crucial protein involved in the assembly and stabilization of the mitochondrial respiratory chain complex I. This complex is essential for cellular respiration as it plays a vital role in the electron transport chain, facilitating ATP production by transferring electrons from NADH to ubiquinone. Mutations in the NDUFAB1 gene have been associated with various mitochondrial disorders, leading to impaired energy metabolism and a range of clinical manifestations. Research on NDUFAB1 recombinant protein has gained significance due to its potential implications in understanding mitochondrial diseases and developing therapeutic strategies. By studying the structure and function of NDUFAB1, scientists aim to elucidate its role in complex I assembly and function, potentially identifying key molecular mechanisms that could be targeted for intervention in mitochondrial dysfunction. Advances in recombinant protein technology enable the production and characterization of NDUFAB1, allowing for detailed investigations into its interactions with other mitochondrial components and its impact on cellular respiration. As ongoing studies seek to uncover the precise biochemical pathways and regulatory networks involving NDUFAB1, this research holds promise for enhancing our understanding of mitochondrial biology and the development of innovative treatments for related disorders. The insights gained from NDUFAB1 studies could pave the way for novel therapeutic approaches, particularly for patients suffering from mitochondrial diseases, thereby highlighting the relevance of this research in both basic science and clinical applications.
