Analytical Data
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基因名
RNASE3
- Application
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别名
RNASE3;ECP;RNS3;Eosinophil cationic Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12724
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表达区间
1-160aa
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氨基酸序列
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNASE3, also known as eosinophil ribonuclease (Eosinophil cationic protein), is a member of the ribonuclease A superfamily and plays a crucial role in the immune response, particularly in allergic reactions and asthma. This protein, predominantly expressed in eosinophils, exhibits potent ribonucleolytic activity and has been implicated in the regulation of inflammation and apoptosis of target cells. Research on RNASE3 has gained considerable interest due to its involvement in various pathological conditions, including asthma, parasitic infections, and certain malignancies. The therapeutic potential of RNASE3 is significant, with studies exploring its use as a biomarker for eosinophilic disorders and its potential application in targeted therapies. Moreover, recombinant RNASE3 proteins are being investigated for their ability to induce apoptosis in cancer cells and modulate immune responses. Understanding the structure-function relationship of RNASE3 through recombinant techniques can provide insights into its biological activity and facilitate the development of novel therapeutic agents. As a result, the study of recombinant RNASE3 not only contributes to basic immunology but also holds promise for translational research in immunotherapy and precision medicine.
