Analytical Data
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Gene name
NCAPH
- Application
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Alternative Names
Barren Drosophila Homolog of 1; Barren homolog protein 1; BRRN; BRRN1; CAP H; CAPH; Chromosome associated protein H; Chromosome-associated protein H; CND2_HUMAN; Condensin complex subunit 2; Condensin subunit 2; Condensin-2 complex subunit H2; Condesin; HCAP H; hCAP-H; KIAA0074; mCAP H; MGC4616; Ncaph; Non SMC condensin I complex subunit H; Non-SMC condensin I complex subunit H; XCAP H homolog; XCAP-H homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15003
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Expression Region
1-741 aa
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AA Sequence
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP VLEDFPQNDD EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP KFTNTQITEH YSTCIKLSTE NKITTKNAFG LHLIDFMSEI LKQKDTEPTN FKVAAGTLDA STKIYAVRVD AVHADVYRVL GGLGKDAPSL EEVEGHVADG SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE IDPMFQKTAA SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF DINAEVDESD CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ SCQEEMISLG DGDIRTMCPL LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF DVYFRKTKAA TILTKSTLEN QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE TEHYEEIEDY DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTALSG KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP VMAQNLSIPL AFACLLHLAN EKNLKLEGTE DLSDVLVRQG D
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Molecular Weight
82.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NCAPH (Nuclear Condensin Complex Subunit 2) is a crucial protein involved in chromosome organization and segregation during cell division. As a component of the condensin complex, NCAPH plays a significant role in maintaining chromosomal stability by facilitating the proper condensation of chromosomes during mitosis and meiosis. Abnormalities in this protein can lead to severe consequences, including aneuploidy and various forms of cancer. Recent studies have highlighted the importance of NCAPH in developmental biology and its potential as a therapeutic target. Understanding the structure and function of NCAPH can provide insights into its mechanistic role in cell cycle regulation and chromosomal dynamics. Researchers are keen to explore NCAPH's interactions with other cellular proteins and its regulation during different phases of the cell cycle. The reconstitution of NCAPH as a recombinant protein allows for detailed biochemical studies, enabling scientists to dissect its functional properties and interactions within the condensin complex. Additionally, investigating the effects of post-translational modifications on NCAPH's activity may elucidate its role in cancer progression and develop targeted strategies for cancer treatment. The ongoing research on NCAPH and its implications in cell division and disease underscores the necessity for continued investigation into its molecular mechanisms and potential applications in biomedical research.
