Analytical Data
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Gene name
RERG
- Application
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Alternative Names
RERG;Ras-related and estrogen-regulated growth inhibitor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96A58
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Expression Region
1-199aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
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Molecular Weight
25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RERG (Ras protein activator like 2, also known as RasGRP2) is a member of the Ras guanine nucleotide exchange factor (GEF) family, which plays a critical role in cellular signaling pathways, particularly in the regulation of the Ras protein family involved in cell proliferation, differentiation, and survival. Research has shown that RERG is implicated in various physiological processes and has notable relevance in cancer biology. Its expression is often downregulated in different types of tumors, suggesting a potential tumor suppressor role. Moreover, RERG has been linked to the modulation of the MAPK/ERK signaling pathway, which is frequently dysregulated in cancer. Investigating the structural and functional properties of the RERG protein is essential for understanding its mechanisms of action and exploring its potential as a therapeutic target. Researchers utilize techniques like protein expression and purification, followed by biochemical assays, to study RERG's interactions with Ras and other signaling molecules. Insights into RERG's regulatory functions could reveal new strategies for cancer treatment and provide a deeper comprehension of tumorigenesis. As a result, the ongoing study of RERG reaffirms its importance in cellular signaling and its potential implications in oncology, highlighting the need for continued research in this promising area.
