Analytical Data
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Gene name
RBBP4
- Application
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Alternative Names
RBBP4;RBAP48;Histone-binding Protein RBBP4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q09028
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Expression Region
2-425aa
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AA Sequence
ADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEDPEGSVDP EGQGS
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBBP4, or Retinoblastoma Binding Protein 4, is a crucial component of the chromatin remodeling machinery and plays a significant role in regulating gene expression, cell cycle progression, and differentiation. Its involvement in the retinoblastoma tumor suppressor pathway highlights its importance in cancer research, particularly in understanding mechanisms of tumorigenesis. Recent studies have demonstrated that RBBP4 interacts with various transcription factors and chromatin remodeling complexes, suggesting its multifaceted role in cellular processes. Additionally, aberrant expression or mutations of RBBP4 have been linked to several types of cancers, implying its potential as a biomarker for cancer diagnosis and prognosis. The recombinant expression of RBBP4 allows for detailed studies of its biochemical properties, functional interactions, and role in chromatin dynamics. These investigations can provide insights into its mechanisms of action, paving the way for the development of novel therapeutic strategies targeting RBBP4 in cancer therapy and other diseases where dysregulation of chromatin structure is implicated. Overall, RBBP4 research continues to be a promising avenue in understanding fundamental biological processes and potential applications in medical science.
