Analytical Data
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基因名
RASSF3
- Application
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别名
RASSF3;Ras association domain-containing Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86WH2
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表达区间
1-238aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMSSGYSS LEEDAEDFFF TARTSFFRRA PQGKPRSGQQ DVEKEKETHS YLSKEEIKEK VHKYNLAVTD KLKMTLNSNG IYTGFIKVQM ELCKPPQTSP NSGKLSPSSN GCMNTLHISS TNTVGEVIEA LLKKFLVTES PAKFALYKRC HREDQVYACK LSDREHPLYL RLVAGPRTDT LSFVLREHEI GEWEAFSLPE LQNFLRILDK EEDEQLQNLK RRYTAYRQKL EEALREVWKP D
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASSF3, a member of the Ras association domain family, plays a crucial role in various cellular processes, including cell proliferation, apoptosis, and response to stress signals. Initially identified as a tumor suppressor, RASSF3's expression levels have been linked to different types of cancers, indicating its potential role in tumorigenesis. Research has shown that RASSF3 interacts with several key signaling pathways, particularly those involving the RAS protein, thereby influencing the downstream effects on cell cycle regulation and apoptosis. Furthermore, the functional loss or mutation of RASSF3 can lead to dysregulated cellular growth and survival, contributing to cancer development. Recent studies utilizing recombinant RASSF3 proteins have provided insights into its molecular mechanisms and interactions, paving the way for deeper understanding of its tumor-suppressive functions. These findings highlight the importance of exploring RASSF3 in cancer research, as it may offer novel therapeutic targets and strategies for intervention in malignancies associated with its loss of function. Overall, ongoing investigations into the biochemical properties and signaling roles of RASSF3 are essential for elucidating its contributions to cancer biology and potentially developing targeted therapies for malignancies.
