Analytical Data
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Gene name
NAB2
- Application
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Alternative Names
EGR 1 binding protein 2; EGR-1-binding protein 2; EGR1 binding protein 2; MADER; Melanoma associated delayed early response protein; Melanoma-associated delayed early response protein; MGC75085; Nab 2; nab2; NAB2_HUMAN; NGFI A binding protein 2 (EGR1 binding protein 2); NGFI A binding protein 2; NGFI-A-binding protein 2; Protein MADER
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15742
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Expression Region
1-525 aa
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AA Sequence
MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG DPRIWPGRST PESDVGAGGE EEAGSPPFSP PAGGGVPEGT GAGGLAAGGT GGGPDRLEPE MVRMVVESVE RIFRSFPRGD AGEVTSLLKL NKKLARSVGH IFEMDDNDSQ KEEEIRKYSI IYGRFDSKRR EGKQLSLHEL TINEAAAQFC MRDNTLLLRR VELFSLSRQV ARESTYLSSL KGSRLHPEEL GGPPLKKLKQ EVGEQSHPEI QQPPPGPESY VPPYRPSLEE DSASLSGESL DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ
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Molecular Weight
56.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NAB2 (Nuclear RNA-binding protein 2) is a member of the NAB family of proteins, which are known to play critical roles in post-transcriptional regulation and RNA metabolism. It has garnered significant attention in recent years due to its involvement in various cellular processes, including gene expression, RNA splicing, and nuclear export. Research has shown that NAB2 interacts with a variety of RNA species and other proteins, influencing several physiological pathways. Its dysregulation has been implicated in the etiology of several diseases, including cancer and neurodegenerative disorders. In particular, mutations and aberrant expression of NAB2 have been linked to tumorigenesis, highlighting its potential as a biomarker and therapeutic target. The study of NAB2, particularly its recombinant protein form, enables researchers to elucidate its functional mechanisms and interactions at a molecular level. By producing NAB2 as a recombinant protein, scientists can investigate its structural properties, binding affinities, and effects on RNA processing, thereby advancing our understanding of its biological significance. Additionally, such studies may pave the way for the development of novel interventions aimed at correcting the pathological effects associated with NAB2 dysregulation. Overall, the research surrounding NAB2 and its recombinant protein facilitates a deeper comprehension of RNA-binding proteins in health and disease, underscoring their importance in the intricate regulatory networks that govern cellular function.
