Analytical Data
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基因名
RAMP1
- Application
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别名
RAMP1;Receptor activity-modifying Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60894
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表达区间
27-117aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSCQEANYG ALLRELCLTQ FQVDMEAVGE TLWCDWGRTI RSYRELADCT WHMAEKLGCF WPNAEVDRFF LAVHGRYFRS CPISGRAVRD PPGS
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAMP1 (Receptor Activity-Modifying Protein 1) is a crucial molecular component that modulates the function of G protein-coupled receptors (GPCRs), particularly the calcitonin gene-related peptide (CGRP) receptor. It plays a significant role in enhancing receptor signaling and specificity, influencing various physiological processes such as vasodilation, pain perception, and neurogenic inflammation. The study of RAMP1 has gained prominence due to its implications in various pathophysiological conditions, including migraine and cardiovascular diseases. Research has demonstrated that RAMP1 can influence the pharmacological properties of CGRP receptors, making it a potential therapeutic target for designing novel drugs to alleviate migraine symptoms and manage cardiovascular health. Additionally, investigations into the structural and functional characteristics of RAMP1 provide insights into GPCR biology and signaling pathways, enhancing our understanding of receptor modulation. Given the increasing recognition of GPCRs in drug discovery, RAMP1 research is essential for elucidating the molecular mechanisms underlying receptor function and developing effective strategies for therapeutic intervention. Thus, RAMP1 serves as a significant focus in both basic and applied biomedical research, with the potential to pave the way for innovative treatments for chronic conditions related to dysregulated receptor activity.
