Analytical Data
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Gene name
RABIF
- Application
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Alternative Names
RABIF;MSS4;RASGRF3;Guanine nucleotide exchange factor MSS4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P47224
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Expression Region
1-123aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MEPAEQPSELVSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK KPALSDGSNP DGDLLQEHWL VEDMFIFENV GFTKDVGNIK FLVCADCEIG PIGWHCLDDK NSFYVALERV SHE
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RABIF, a member of the RAS oncogene family, plays a crucial role in intracellular trafficking and membrane dynamics. It is particularly involved in the regulation of vesicle transport, influencing various cellular processes such as endocytosis and exocytosis. Research has indicated that RABIF may interact with several protein partners, suggesting its potential involvement in critical signaling pathways related to cell growth and differentiation. The interest in RABIF has increased due to its implications in diseases, particularly cancer, where dysregulation of vesicular transport can contribute to tumor progression and metastasis. Studies focusing on RABIF recombinantly expressed proteins have aimed to elucidate its functional mechanisms, interactions, and potential as a therapeutic target. By employing techniques such as protein crystallography and biochemical assays, researchers strive to uncover the structural and functional characteristics of RABIF that could lead to novel insights into its role in health and disease. Understanding RABIF's function at a molecular level could provide a foundation for developing new strategies in targeting cancer and other diseases associated with RABIF dysregulation.
