Analytical Data
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基因名
QPRT
- Application
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别名
QPRT;Nicotinate-nucleotide pyrophosphorylase [carboxylating]
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15274
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表达区间
1-297aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMDAEGLALLLPPVTLAALVDSWLREDCPGL NYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSK LVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGW TGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGG VEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELH PTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALD FSLKLFAKEVAPVPKIH
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on QPRT (Quinolinate Phosphoribosyltransferase) has gained significant attention due to its role in the metabolism of tryptophan and its potential implications in various neurological disorders. QPRT is an enzyme that catalyzes the conversion of quinolinic acid, a neurotoxic metabolite, into nicotinamide adenine dinucleotide (NAD+), which is vital for cellular energy production and maintaining neuronal health. Dysregulation of QPRT activity can lead to elevated levels of quinolinic acid, which has been associated with neurodegenerative diseases such as Alzheimer's and Huntington's disease. Given the enzyme's critical function in the kynurenine pathway, researchers are investigating QPRT's structural properties and regulatory mechanisms to understand its therapeutic potential. Additionally, the enzyme's involvement in the immune response and neuroinflammation underscores the importance of QPRT in maintaining brain homeostasis. Insights gained from these studies could pave the way for the development of novel therapeutic strategies aimed at modulating QPRT activity, ultimately contributing to improved outcomes for patients with neurological disorders.
