Analytical Data
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Gene name
QKI
- Application
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Alternative Names
QKI;HKQ;KH domain-containing RNA-binding Protein QKI
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96PU8
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Expression Region
1-341aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
QKI (quaking homolog, type I) is a RNA-binding protein that plays a crucial role in various biological processes, including myelination, neural development, and the regulation of gene expression. Its importance has garnered significant attention in the field of molecular and cellular biology, particularly in neurological studies. The QKI protein exists in multiple isoforms, which are generated through alternative splicing and exhibit distinct functions and expression patterns in different cell types. Research on QKI has revealed its involvement in the regulation of mRNA stability and translation, highlighting its potential role in various diseases, such as multiple sclerosis and various cancers. Additionally, studies have demonstrated that QKI contributes to the proliferation and differentiation of oligodendrocyte precursor cells, making it a focal point in myelin repair and regeneration research. Understanding the molecular mechanisms underlying QKI’s function and its interaction with RNA and other cellular components is crucial for developing therapeutic strategies aimed at demyelinating diseases and other QKI-related pathologies. The ongoing exploration of QKI recombinant proteins provides valuable insights into its functional characteristics and opens avenues for the examination of its role in disease models, thereby advancing our knowledge of neural development and regeneration.
