Analytical Data
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Gene name
GBP1
- Application
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Alternative Names
GBP1；Guanylate-binding Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32455
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Expression Region
1-592aa
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AA Sequence
MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTG KSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEG LGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTH RIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDE YLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQL EKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESL QELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQ EASSDRCSGLLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEE PRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQ ASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTL ALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
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Molecular Weight
91 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GBP1 (Guanylate-Binding Protein 1) is a member of the GBP family, which plays a crucial role in the innate immune response, particularly in the defense against viral and intracellular bacterial infections. It is characterized by its ability to bind to guanosine triphosphate (GTP) and its function as an interferon-induced protein, highlighting its importance in host-pathogen interactions. Research has shown that GBP1 is involved in various cellular processes, including protein synthesis, cell proliferation, and the modulation of inflammatory responses. The protein's role in autophagy and the regulation of cellular apoptosis further emphasizes its significance in immune signaling pathways. Given its diverse functions, GBP1 has garnered attention in the fields of immunology, virology, and cancer research, particularly concerning its potential as a therapeutic target. Studies have indicated that manipulating GBP1 expression can influence the outcome of infections and tumor progression, making it a promising candidate for therapeutic interventions. Understanding the molecular mechanisms underpinning GBP1's actions will not only advance our knowledge of innate immunity but may also pave the way for novel treatment strategies for infectious diseases and malignancies. As the scientific community continues to unravel the complexities of GBP1, its implications for vaccine development and the enhancement of immune responses against various pathogens are of particular interest, potentially leading to innovative approaches in immunotherapy and vaccine design.
