Analytical Data
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Gene name
PTGR2
- Application
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Alternative Names
PTGR2;ZADH1;Prostaglandin reductase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N8N7
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Expression Region
1-351aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMIVQRV VLNSRPGKNG NPVAENFRME EVYLPDNINE GQVQVRTLYL SVDPYMRCRM NEDTGTDYIT PWQLSQVVDG GGIGIIEESK HTNLTKGDFV TSFYWPWQTK VILDGNSLEK VDPQLVDGHL SYFLGAIGMP GLTSLIGIQE KGHITAGSNK TMVVSGAAGA CGSVAGQIGH FLGCSRVVGI CGTHEKCILL TSELGFDAAI NYKKDNVAEQ LRESCPAGVD VYFDNVGGNI SDTVISQMNE NSHIILCGQI SQYNKDVPYP PPLSPAIEAI QKERNITRER FLVLNYKDKF EPGILQLSQW FKEGKLKIKE TVINGLENMG AAFQSMMTGG NIGKQIVCIS EEISL
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTGR2, or Prostaglandin-Tyrosine-Protein Kinase Receptor 2, is a crucial enzyme implicated in the metabolic pathways of prostaglandins, which are bioactive lipids that play a significant role in various physiological processes, including inflammation, pain, and regulation of vascular functions. Recent studies have highlighted the importance of PTGR2 in the pathophysiology of several diseases, including cancer, cardiovascular disorders, and metabolic syndromes. As researchers continue to explore the intricate mechanisms underlying these diseases, PTGR2 has emerged as a potential therapeutic target. The recombinant expression of PTGR2 provides an avenue for elucidating its structural and functional properties. By studying the recombinant protein, scientists aim to better understand its enzymatic activity, interaction with substrates, and modulation by other cellular factors. This knowledge can lay the groundwork for the development of novel inhibitors or activators that can be used in drug design, potentially leading to more effective treatment strategies. Furthermore, the production of recombinant PTGR2 can facilitate high-throughput screening of compounds that impact its activity, thus accelerating drug discovery processes. Therefore, the investigation of PTGR2 as a recombinant protein holds promise not only for advancing our understanding of its biological roles but also for contributing to the development of new therapeutic interventions in various disease contexts.
