Analytical Data
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基因名
MRPS23
- Application
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别名
Small ribosomal subunit protein mS23. 28S ribosomal protein S23. mitochondrial. MRP-S23. S23mt
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3D9
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表达区间
1-190 aa
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氨基酸序列
MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLRGPVFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP
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分子量
46.64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPS23, or Mitochondrial Ribosomal Protein S23, is a crucial component of the mitochondrial ribosome, involved in the synthesis of proteins essential for mitochondrial function and energy production. Research into MRPS23 has gained significance due to its potential implications in various mitochondrial disorders and inherited diseases, which often result from mitochondrial dysfunction. Mitochondria are the powerhouses of the cell, playing a pivotal role in ATP generation, and any disruption in their protein synthesis machinery can lead to severe metabolic problems. The interest in MRPS23 also stems from its role in the regulation of mitochondrial translation, which is distinct from the cytosolic translation process. Understanding the structure and function of MRPS23 could provide insights into the mechanisms underlying mitochondrial diseases and inform therapeutic approaches. Recent studies have highlighted the importance of mitochondrial ribosomal proteins, like MRPS23, in maintaining mitochondrial integrity and function, thus making it a compelling target for research aimed at developing treatments for conditions linked to mitochondrial dysfunction. Notably, advances in techniques such as cryo-electron microscopy have enabled detailed examination of mitochondrial ribosomes, unveiling the intricate relationships between protein components like MRPS23 and their functional roles. This has set the stage for further exploration into how mutations in MRPS23 may contribute to disease phenotypes, emphasizing the need for an integrated understanding of mitochondrial biology in both health and disease contexts. Overall, the study of MRPS23 is an emerging field that bridges molecular biology, genetics, and medicine, highlighting its potential as a therapeutic target for ameliorating mitochondrial-related disorders.












