Analytical Data
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基因名
MRPL43
- Application
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别名
MRPL43; 39S ribosomal protein L43; mitochondrial; L43mt; MRP-L43; Mitochondrial large ribosomal subunit protein mL43; Mitochondrial ribosomal protein bMRP36a
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N983
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表达区间
1-159 aa
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氨基酸序列
MTARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREVIDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLVQKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQDPAPAQVQAQ
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分子量
44.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL43, a member of the mitochondrial ribosomal protein family, plays a crucial role in mitochondrial translation and protein synthesis, which are essential for maintaining mitochondrial function and energy production. Research into MRPL43 has gained significance due to its potential involvement in various metabolic disorders and age-related diseases, where mitochondrial dysfunction is a key factor. Studies have shown that alterations in mitochondrial ribosomal proteins can lead to impaired protein synthesis, affecting mitochondrial biogenesis and overall cellular health. Given the rising prevalence of diseases associated with mitochondrial dysfunction, including neurodegenerative disorders and cancers, understanding the structure and function of MRPL43 is essential. Recent advances in recombinant protein technology have enabled scientists to produce MRPL43 in sufficient quantities for biochemical and structural studies. By characterizing the functional properties of MRPL43 through techniques such as crystallography and NMR spectroscopy, researchers aim to elucidate its role in mitochondrial dynamics and its interactions with other cellular components. This research is pivotal for developing therapeutic strategies that target mitochondrial dysfunction, potentially leading to novel treatments for diseases linked to MRPL43 dysregulation. In conclusion, MRPL43 serves as a vital link in the complex network of mitochondrial biology, making it a promising focus for further investigation in the quest to understand and combat mitochondrial diseases.
