Analytical Data
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Gene name
PSMA6
- Application
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Alternative Names
PSMA6;PROS27;Proteasome subunit alpha type-6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60900
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Expression Region
1-246aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSHMSRGSSAGFDRHITIFSPEGRLYQVE YAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENI GCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYT QNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTEST SFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPK FRILTEAEIDAHLVALAERD
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMA6, a vital component of the 26S proteasome, plays a crucial role in protein degradation and cellular regulation. This protein is part of the proteasome's catalytic core, specifically influencing the degradation of ubiquitinated substrates, which is essential for various cellular processes, including the cell cycle, apoptosis, and the regulation of signaling pathways. Dysregulation of proteasomal activity, including that involving PSMA6, has been implicated in a range of diseases, particularly cancers and neurodegenerative disorders. Recent studies have highlighted the potential of PSMA6 as a biomarker for certain malignancies, as well as its role in the immune response. Furthermore, the recombinant expression of PSMA6 provides an opportunity to explore its functional properties and interactions with other proteasomal subunits and substrates. By studying the recombination and characterization of PSMA6, researchers aim to better understand its mechanisms of action and potential therapeutic applications, paving the way for new strategies in drug design and disease management targeting proteasomal dysfunction.
