Analytical Data
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Gene name
HRH2
- Application
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Alternative Names
HRH2；Histamine H2 receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25021
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Expression Region
1-359aa
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AA Sequence
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HRH2, or the Histamine Receptor H2, is a crucial component of the histamine signaling system and plays a significant role in various physiological processes, including the regulation of gastric acid secretion, neurotransmission, and immune responses. Research into HRH2 recombinant proteins has gained momentum due to their therapeutic potential in treating conditions such as gastric disorders, allergic reactions, and other histamine-related ailments. Understanding HRH2's function and structure at a molecular level is essential for the development of targeted drugs that can modulate its activity. Recombinant HRH2 proteins serve as vital tools for studying receptor binding mechanisms, downstream signaling pathways, and interactions with various ligands, which can unveil new insights into histamine’s role in health and disease. Furthermore, HRH2-based therapeutic approaches, including the design of selective agonists and antagonists, hold promise for advancing clinical treatments for disorders associated with dysregulated histamine signaling. As the understanding of HRH2 continues to evolve, the application of recombinant technology in this field is likely to pave the way for innovative strategies to manipulate receptor activity, enhance drug efficacy, and minimize adverse effects, ultimately contributing to improved healthcare outcomes.
