Analytical Data
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基因名
CALY
- Application
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别名
CALY；DRD1IP；Neuron-specific vesicular Protein calcyon
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYX4
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表达区间
1-217aa
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氨基酸序列
MVKLGCSFSGKPGKDPGDQDGAAMDSVPLISPLDISQLQPPLPDQVVIKTQTEYQLSSPDQQNFPDLEGQRLNCSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKGPTQAGAAAAATEPPGKPSAKAEKEAARKAAGSAAPPPAQ
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分子量
23.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CALY, or Calreticulin, is a ubiquitous calcium-binding chaperone protein found in the endoplasmic reticulum, playing a pivotal role in various cellular processes, including protein folding, assembly, and quality control. Its significance extends to immune response regulation, influencing T-cell activation and the presentation of antigens. Recent research has focused on the implications of CALY in different diseases, particularly in cancer, where its aberrant expression has been linked to tumor progression and immune evasion. The recombinant production of CALY has gained attention as it enables the detailed study of its structure, function, and potential therapeutic applications. By expressing CALY in a controlled environment, researchers can investigate its properties, interactions with other proteins, and its role in pathophysiological conditions. Understanding CALY through recombinant techniques may lead to novel insights into its function in immune modulation and inform the development of targeted therapies, enhancing our strategies against various diseases, particularly tumors that exploit CALY's mechanisms for immune evasion.
