Analytical Data
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Gene name
PLCe1
- Application
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Alternative Names
PLCe1；KIAA1516；PLCE；PPLC；1-phosphatidylinositol 4.5-bisphosphate phosphodiesterase epsilon-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P212
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
258.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLCe1, or Phospholipase C epsilon 1, is an important enzyme that plays a pivotal role in various signaling pathways within cells. It is part of the phospholipase C family, which is involved in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol trisphosphate (IP3) and diacylglycerol (DAG), key molecules in cellular signaling. The study of PLCe1 has gained prominence due to its involvement in numerous physiological processes, including cell proliferation, differentiation, and apoptosis, as well as its implications in various diseases such as cancer and cardiovascular disorders. Researchers have focused on recombinant PLCe1 protein to understand its structure-function relationships, regulatory mechanisms, and interaction with other cellular components. By cloning and expressing PLCe1 in host systems, scientists can produce active protein for detailed biochemical characterization and functional studies. Additionally, understanding PLCe1's role in disease states could pave the way for novel therapeutic targets, enhancing our ability to design drugs that modulate its activity in specific pathological conditions. The ongoing research into PLCe1 not only deepens our understanding of cellular signaling networks but also contributes to the broader field of molecular biology and drug development.
