Analytical Data
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Gene name
PRKRA
- Application
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Alternative Names
PRKRA;PACT;RAX;Interferon-inducible double-stranded RNA-dependent Protein kinase activator A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75569
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Expression Region
1-313aa
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AA Sequence
MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA KFSNISPENH ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD YIQLLSEIAK EQGFNITYLD IDELSANGQY QCLAELSTSP ITVCHGSGIS CGNAQSDAAH NALQYLKIIA ERK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRKRA (protein kinase, interferon-inducible double-stranded RNA-dependent activator) is a critical player in the cellular response to viral infections and stress. This protein is known to interact with the double-stranded RNA (dsRNA) that is often produced during viral replication, acting as a sensor that triggers the innate immune response. Research indicates that PRKRA plays a significant role in the regulation of apoptosis and interferon production, making it essential for maintaining cellular homeostasis and antiviral defense mechanisms. Studies have shown that PRKRA is involved in the activation of PKR (protein kinase R), which is crucial for inhibiting viral protein synthesis and inducing apoptosis in infected cells. Mutations or dysregulation of PRKRA have been linked to various diseases, including cancer and autoimmune disorders, highlighting its potential as a therapeutic target. The characterization of PRKRA and its recombinant forms has garnered interest in understanding its structural and functional properties, which could lead to innovative strategies in vaccine development and antiviral therapies. By elucidating the molecular mechanisms underlying PRKRA's activities, researchers aim to harness its potential in boosting the immune response against infections and in managing diseases associated with its dysfunction.
