Cat: PA2000-9436

Recombinant Human MR1 Protein,GST

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Analytical Data

  • 基因名

    MR1

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Major histocompatibility complex class I-related protein 1. MHC class I-related protein 1. Class I histocompatibility antigen-like protein

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q95460

  • 表达区间

    201-300 aa

  • 氨基酸序列

    TEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPL

  • 分子量

    36.74 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

MR1 (MHC class I-related molecule 1) is a non-classical major histocompatibility complex protein that plays a crucial role in the immune system, particularly in presenting vitamin B metabolites to MAIT (mucosal-associated invariant T) cells. These T cells are a unique subset of innate-like lymphocytes that bridge the innate and adaptive immune responses. MR1's primary function involves recognizing microbial-derived vitamin metabolites and initiating a rapid immune response, making it essential in the defense against various infections, especially those caused by bacteria. Given the rising interest in targeting MR1 for immunotherapies, researchers have been working to understand its structure, function, and the mechanisms by which it activates MAIT cells. Notably, MR1's ability to present antigens in a non-traditional manner distinguishes it from classical MHC molecules, thus opening new avenues for drug development and vaccine strategies. Furthermore, MR1 has been implicated in various diseases, including cancer and autoimmune disorders, suggesting that modulation of MR1 interactions may have therapeutic potential. The study of MR1 and its interactions not only enhances our understanding of immune evasion by pathogens but may also contribute to the development of novel immunotherapeutic approaches aimed at harnessing this unique immune pathway. As such, MR1 research stands at the forefront of immunology, with significant implications for improving human health through innovative therapies leveraging the immune system's mechanisms.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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