Analytical Data
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基因名
LRP11
- Application
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别名
LRP11；Low-density lipoProtein receptor-related Protein 11
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86VZ4
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表达区间
1-450aa
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氨基酸序列
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS SSGKNRKEES YIFESKGDGG GGEHPAPETG
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP11, or Low-Density Lipoprotein Receptor-Related Protein 11, is a member of the LDL receptor family and has gained attention for its potential roles in various biological processes and disease mechanisms. This protein is implicated in lipid metabolism, cell signaling, and the regulation of neurodegenerative diseases, making it a significant candidate for therapeutic exploration. Studies have shown that LRP11 may influence cellular uptake of lipoproteins and modulate inflammatory responses, suggesting its involvement in a variety of pathophysiological conditions. The interest in LRP11 is particularly heightened due to its differential expression in several tissues and its potential link to conditions such as Alzheimer's disease and other cognitive disorders. Research efforts have focused on understanding the functional characteristics of LRP11, including its interactions with other cellular receptors and its role in governing intracellular trafficking. Furthermore, the development of recombinant LRP11 proteins has provided tools for elucidating its biological functions and molecular mechanisms. Identifying the precise pathways and targets that LRP11 influences may lead to novel therapeutic strategies for disorders where lipoprotein metabolism is disrupted or where LRP11 itself shows aberrant expression. Overall, ongoing research aims to clarify the role of LRP11 in health and disease, paving the way for future studies that could leverage this knowledge for innovative clinical applications.
