Analytical Data
-
Gene name
LRP11
- Application
-
Alternative Names
LRP11；Low-density lipoProtein receptor-related Protein 11
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q86VZ4
-
Expression Region
1-450aa
-
AA Sequence
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS SSGKNRKEES YIFESKGDGG GGEHPAPETG
-
Molecular Weight
45 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRP11, or Low-Density Lipoprotein Receptor-Related Protein 11, is a member of the LDL receptor family and has gained attention for its potential roles in various biological processes and disease mechanisms. This protein is implicated in lipid metabolism, cell signaling, and the regulation of neurodegenerative diseases, making it a significant candidate for therapeutic exploration. Studies have shown that LRP11 may influence cellular uptake of lipoproteins and modulate inflammatory responses, suggesting its involvement in a variety of pathophysiological conditions. The interest in LRP11 is particularly heightened due to its differential expression in several tissues and its potential link to conditions such as Alzheimer's disease and other cognitive disorders. Research efforts have focused on understanding the functional characteristics of LRP11, including its interactions with other cellular receptors and its role in governing intracellular trafficking. Furthermore, the development of recombinant LRP11 proteins has provided tools for elucidating its biological functions and molecular mechanisms. Identifying the precise pathways and targets that LRP11 influences may lead to novel therapeutic strategies for disorders where lipoprotein metabolism is disrupted or where LRP11 itself shows aberrant expression. Overall, ongoing research aims to clarify the role of LRP11 in health and disease, paving the way for future studies that could leverage this knowledge for innovative clinical applications.
