Cat: PA1000-2508

Recombinant Human PRKAB2 Protein,His

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Analytical Data

  • 基因名

    PRKAB2

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    PRKAB2;5'-AMP-activated Protein kinase subunit beta-2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    O43741

  • 表达区间

    1-272aa

  • 氨基酸序列

    MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI

  • 分子量

    57.3kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

PRKAB2, or Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2, is a vital component of the AMP-activated protein kinase (AMPK) complex, which plays a crucial role in cellular energy homeostasis. The increasing prevalence of metabolic disorders, such as obesity and type 2 diabetes, has led to heightened interest in understanding the regulatory mechanisms of AMPK, as it helps monitor and respond to cellular energy levels. Research has indicated that PRKAB2, as a non-catalytic subunit, is involved in modulating AMPK activity in response to environmental stressors, thus impacting various physiological processes, including glucose uptake, lipid metabolism, and cell growth. Additionally, mutations or dysregulation in PRKAB2 have been associated with metabolic dysfunctions, making it a potential therapeutic target. Studies involving PRKAB2 recombinant proteins can provide insights into its structural and functional characteristics, elucidating its role in AMPK signaling pathways. The exploration of PRKAB2 not only enhances our understanding of energy regulation in cells but also opens avenues for developing novel strategies for treating metabolic diseases. This research emphasizes the significance of PRKAB2 in maintaining metabolic balance and its potential implications in therapeutic interventions for metabolic disorders, highlighting the relevance of recombinant protein studies in advancing our knowledge in this field.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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