Analytical Data
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Gene name
PPP3CA
- Application
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Alternative Names
PPP3R1;CNA2;CNB;Calcineurin subunit B type 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08209-2
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Expression Region
1-511aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHTGSMSEPKAIDPKLSTTDRVVKAVPFPPSH RLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKN LLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSI ECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDA CMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPM CDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSI LRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENN VMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL GSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLT PTGMLPSGVLSGGKQTLQSAIKGFSPQHKITSFEEAKGLDRINERMPPRR DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP3CA, the gene encoding the catalytic subunit of protein phosphatase 3 (PP3), plays a critical role in various cellular processes, including cell cycle regulation, differentiation, and apoptosis. As a serine/threonine phosphatase, PPP3CA is involved in dephosphorylating target proteins, thus modulating signaling pathways that are crucial for cellular responses to environmental stimuli. Abnormal regulation of PPP3CA has been implicated in a range of diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Research into recombinant PPP3CA protein aims to elucidate its enzymatic properties and biological functions, providing insights into its mechanisms of action and potential therapeutic targets. Characterizing this protein through recombinant technology enables the production of large quantities necessary for biochemical assays, structural studies, and drug discovery efforts. Understanding the structure-function relationship of PPP3CA is essential for developing specific inhibitors or activators that could have therapeutic implications. Additionally, studying PPP3CA's interactions with other proteins and its regulatory mechanisms can contribute to our knowledge of its role in health and disease, paving the way for innovative treatment strategies.
