Analytical Data
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Gene name
CDK20
- Application
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Alternative Names
CDK20；CCRK；CDCH；Cyclin-dependent kinase 20
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IZL9
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Expression Region
1-346aa
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AA Sequence
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR EIKALQEMED NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWSV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQVPMPL EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG
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Molecular Weight
38.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK20 (Cyclin-dependent kinase 20) is a member of the cyclin-dependent kinase family, which plays a vital role in regulating the cell cycle and various cellular processes. Recent studies have highlighted its significance in controlling cell proliferation and its potential involvement in cancer progression. CDK20's unique function in phosphorylating specific target proteins may influence gene expression and cellular responses to stress, making it a focus of interest for researchers examining tumor biology. Given that dysregulation of the cell cycle is a hallmark of cancer, understanding the role of CDK20 in cancerous cells could provide insights into new therapeutic strategies. Moreover, the ability to produce and characterize recombinant CDK20 protein offers an invaluable tool for elucidating its biochemical properties and interactions. This research could pave the way for developing targeted treatments that inhibit CDK20's activity in cancer cells, thereby contributing to improved patient outcomes. The exploration of CDK20's role in various signaling pathways and its potential as a biomarker or therapeutic target continues to gather momentum in the field of cancer research.
