Analytical Data
-
Gene name
CDK18
- Application
-
Alternative Names
CDK18；PCTAIRE3；PCTK3；Cyclin-dependent kinase 18
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q07002
-
Expression Region
1-472aa
-
AA Sequence
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGR DPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMD IRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGE GTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANI VTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVV TLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHL IFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLL SSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKD PGYRGLAFQQPGRGKNRRQSIF
-
Molecular Weight
76 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDK18, a member of the cyclin-dependent kinase (CDK) family, plays a crucial role in the regulation of the cell cycle and transcription processes. Its involvement in various cellular functions has drawn attention to its potential implications in cancer and other diseases. Previous studies have indicated that CDK18 is implicated in modulating the activity of transcription factors and influencing RNA polymerase II function, thereby affecting gene expression. Research has also shown that CDK18 interacts with various cellular pathways, including those related to cell proliferation, DNA repair, and stress responses. The understanding of CDK18's role has been enhanced by advances in recombinant protein technology, allowing for the production of large quantities of the protein for detailed biochemical and biophysical characterization. Investigating the structure, dynamics, and interactions of CDK18 through recombinant protein studies can reveal insights into its functional mechanisms and regulatory pathways. Furthermore, given its involvement in oncogenic processes, CDK18 could represent a potential therapeutic target, making the exploration of its recombinant protein not only significant for basic research but also for future drug development strategies.
