Analytical Data
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基因名
CDK18
- Application
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别名
CDK18；PCTAIRE3；PCTK3；Cyclin-dependent kinase 18
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07002
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表达区间
1-472aa
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氨基酸序列
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGR DPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMD IRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGE GTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANI VTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVV TLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHL IFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLL SSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKD PGYRGLAFQQPGRGKNRRQSIF
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分子量
76 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK18, a member of the cyclin-dependent kinase (CDK) family, plays a crucial role in the regulation of the cell cycle and transcription processes. Its involvement in various cellular functions has drawn attention to its potential implications in cancer and other diseases. Previous studies have indicated that CDK18 is implicated in modulating the activity of transcription factors and influencing RNA polymerase II function, thereby affecting gene expression. Research has also shown that CDK18 interacts with various cellular pathways, including those related to cell proliferation, DNA repair, and stress responses. The understanding of CDK18's role has been enhanced by advances in recombinant protein technology, allowing for the production of large quantities of the protein for detailed biochemical and biophysical characterization. Investigating the structure, dynamics, and interactions of CDK18 through recombinant protein studies can reveal insights into its functional mechanisms and regulatory pathways. Furthermore, given its involvement in oncogenic processes, CDK18 could represent a potential therapeutic target, making the exploration of its recombinant protein not only significant for basic research but also for future drug development strategies.
