Cat: PA2000-9405

Recombinant Human MOBKL2B Protein,His

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Analytical Data

  • 基因名

    MOBKL2B

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    MOB3B; C9orf35; MOBKL2B; MOB kinase activator 3B; Mob1 homolog 2b; Mps one binder kinase activator-like 2B; MOB kinase activator-like 2B

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q86TA1

  • 表达区间

    1-216 aa

  • 氨基酸序列

    MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL PSGEDQNDWV AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW QDDLKYKKPT ALPAPQYMNL LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI CKKILCRLFR VFVHVYIHHF DRVIVMGAEA HVNTCYKHFY YFVTEMNLID RKELEPLKEM TSRMCH

  • 分子量

    25.4 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

MOBKL2B, a member of the MOB (Mps One Binder) protein family, plays a crucial role in various cellular processes, including cell cycle regulation, mitotic progression, and signal transduction. Its involvement in the Hippo pathway, which is pivotal for controlling cell growth and organ size, has garnered significant attention in recent years. Dysregulation of MOBKL2B has been associated with several cancers, making it a potential target for therapeutic interventions. Studies have shown that MOBKL2B interacts with various kinases, particularly LATS1/2, influencing the phosphorylation and activation state of downstream effectors like YAP/TAZ, which are key modulators of cell proliferation and apoptosis. Given its importance in tumorigenesis and cellular homeostasis, the production and characterization of recombinant MOBKL2B protein have become an essential step in elucidating its structure-function relationships. Researchers aim to explore its biochemical properties, functional roles, and therapeutic potentials by using techniques like X-ray crystallography and NMR spectroscopy. Additionally, understanding how MOBKL2B regulates key cellular pathways may pave the way for novel cancer treatment strategies and contribute to the development of biomarker platforms for early cancer detection and prognosis. Therefore, the study of MOBKL2B recombinant protein not only enhances our knowledge of fundamental biological processes but also opens avenues for innovative cancer therapies.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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