Analytical Data
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Gene name
Slc17a6
- Application
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Alternative Names
Slc17a6；DNPI；VGLUT2；Vesicular glutamate transporter 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P2U8
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Expression Region
1-582aa
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AA Sequence
MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS
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Molecular Weight
64.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC17A6, also known as VGLUT2, is a critical member of the SLC17 family of transporters, primarily involved in the uptake of glutamate, a major neurotransmitter in the central nervous system. Its functional significance in neurotransmission and synaptic plasticity has garnered substantial attention from researchers, especially given its role in excitatory signaling pathways. Abnormalities in SLC17A6 expression and function have been implicated in various neurological disorders, including schizophrenia, autism, and epilepsy. Understanding the structural and functional characteristics of SLC17A6 is vital for elucidating its role in health and disease. The study of recombinant SLC17A6 protein allows for the exploration of its biochemical properties and transport mechanisms in a controlled environment. By expressing the protein in heterologous systems, researchers can investigate its interaction with other proteins, characterize its substrate specificity, and identify potential inhibitors. Such studies not only contribute to a deeper understanding of glutamate transport dynamics but may also facilitate the development of therapeutic strategies targeting SLC17A6-related pathologies. Overall, the research on recombinant SLC17A6 protein serves as a cornerstone in unraveling the complexities of synaptic transmission and provides insights into potential interventions for neurotransmitter imbalance in various neurological conditions.
