Analytical Data
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基因名
GTF3A
- Application
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别名
GTF3A；Transcription factor IIIA
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92664
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表达区间
1-365aa
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氨基酸序列
MDPPAVVAESVSSLTIADAFIAAGESSAPTPPRPALPRRFICSFPDCSANYSKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILTHTGEKPFVCAANGCDQKFNTKSNLKKHFERKHENQQKQYICSFEDCKKTFKKHQQLKIHQCQHTNEPLFKCTQEGCGKHFASPSKLKRHAKAHEGYVCQKGCSFVAKTWTELLKHVRETHKEEILCEVCRKTFKRKDYLKQHMKTHAPERDVCRCPREGCGRTYTTVFNLQSHILSFHEESRPFVCEHAGCGKTFAMKQSLTRHAVVHDPDKKKMKLKVKKSREKRSLASHLSGYIPPKRKQGQGLSLCQNGESPNCVEDKMLSTVAVLTLG
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分子量
41.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GTF3A, or General Transcription Factor 3A, is a critical component of the transcription machinery in eukaryotic cells, playing a significant role in the assembly of the transcription pre-initiation complex. It is essential for RNA polymerase II-mediated transcription, facilitating the recruitment of other transcription factors and RNA polymerase itself to the promoter regions of genes. The study of GTF3A and its recombinant protein has garnered attention due to its implications in fundamental biological processes and its potential link to various diseases, including cancer. The ability to produce recombinant GTF3A in vitro allows researchers to investigate its structural and functional properties, understand its interactions with other transcription factors, and evaluate its role in the regulation of gene expression. Additionally, the GTF3A protein could serve as a valuable tool in the development of gene therapies and novel strategies for cancer treatment, making it a focus of research in molecular biology and therapeutic applications. Understanding the dynamics of GTF3A, particularly through the use of recombinant technology, not only enhances our knowledge of transcription regulation but also opens up new avenues for drug discovery and the treatment of transcription-related disorders.
