Analytical Data
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基因名
MLX
- Application
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别名
MLXIP; BHLHE36; KIAA0867; MIR; MONDOA; MLX-interacting protein; Class E basic helix-loop-helix protein 36; bHLHe36; Transcriptional activator MondoA
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAP2
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表达区间
1-244 aa
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氨基酸序列
MTEPGASPEDPWVKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
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分子量
52.58 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLX, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in regulating various biological processes, including cellular metabolism, proliferation, and differentiation. Recent research has highlighted MLX as a key integrator of metabolic signals, linking nutrient availability to gene expression. Its ability to form heterodimers with other bHLH proteins, such as MondoA, enhances its regulatory capabilities in response to glucose and fatty acid levels. Furthermore, MLX has been implicated in the development of various metabolic disorders, including obesity and diabetes, making it an attractive target for therapeutic intervention. The study of MLX has gained momentum as advanced techniques in molecular biology and biochemistry allow for a deeper understanding of its structural and functional properties. By exploring the mechanisms underlying MLX’s activities, researchers aim to identify potential strategies for modulating its function, potentially leading to novel treatments for metabolic diseases. The continued investigation of MLX and its associated proteins is essential for unraveling the complexities of metabolic regulation and developing innovative approaches to address related health issues.
