Analytical Data
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基因名
MLXIPL
- Application
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别名
carbohydrate response element binding protein; bHLHd14; Carbohydrate responsive element binding protein; Class D basic helix-loop-helix protein 14; MIO; MLX interacting protein like; Mlx interactor; MLX-interacting protein-like; MLXIPL; MONDOB; WBS14_HUMAN; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; Williams-Beuren syndrome chromosomal region 14 protein; WS basic helix loop helix leucine zipper protein; WS basic-helix-loop-helix leucine zipper protein; WS bHLH; WS-bHLH
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NP71
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表达区间
1-217 aa
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氨基酸序列
MDEQGCEHTSRTEDPFIQPTDFGPSEPPLSVPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRPPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPGEPGGETQCGAPPDPEGCFPIPKAFKLVTTTTTLVCTCMRTHIHLNETKVS
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分子量
38.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLXIPL, also known as Carbohydrate Response Element-Binding Protein (ChREBP), is a transcription factor that plays a critical role in glucose and lipid metabolism. Its involvement in metabolic disorders, such as obesity and type 2 diabetes, has garnered significant attention in recent years. Research has shown that MLXIPL regulates the expression of key genes that are responsible for glucose sensing and fatty acid synthesis, making it an essential player in metabolic homeostasis. The regulation of MLXIPL is tightly controlled by various physiological signals, including glucose and insulin levels, highlighting its importance in energy balance and metabolic health. Additionally, abnormal MLXIPL activity has been linked to the development of insulin resistance and dyslipidemia, further emphasizing the need for a deeper understanding of its function and mechanism of action. Researchers are increasingly focusing on MLXIPL as a potential therapeutic target for metabolic diseases, making its recombinant protein an attractive subject of study for elucidating its biological role and potential implications in disease management. Consequently, studies involving MLXIPL recombinant proteins not only aim to clarify its molecular interactions and regulatory pathways but also explore how modulating its activity could present new avenues for treating metabolic disorders and improving overall metabolic health.
