Analytical Data
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Gene name
FCRL3
- Application
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Alternative Names
FCRL3；FCRH3；IFGP3；IRTA3；Fc receptor-like Protein 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96P31
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Expression Region
18-573aa
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AA Sequence
GVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLT
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Molecular Weight
67.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FCRL3, or Fc receptor-like 3, is a member of the Fc receptor family that plays a significant role in the regulation of immune responses. It is predominantly expressed on B cells and is implicated in various immunological functions, including modulation of antibody responses and T cell interactions. The study of FCRL3 has gained attention due to its potential involvement in autoimmune diseases, cancer, and infectious diseases. Research indicates that FCRL3 may act as an inhibitory receptor, influencing B cell activation and differentiation, which can affect the overall immune landscape. Understanding the structure and function of FCRL3 is crucial for deciphering its roles in these pathological conditions. Recombinant FCRL3 proteins have been developed for functional studies to explore its interactions with ligands and signaling pathways. By investigating the mechanisms of action and regulatory functions of FCRL3, researchers aim to unveil novel therapeutic strategies targeting immune dysregulation, providing insights into designing more effective treatments for related diseases. Additionally, FCRL3's involvement in modulating immune checkpoint pathways is increasingly recognized, marking it as a potential candidate for immunotherapy approaches. Therefore, comprehensive studies of recombinant FCRL3 proteins are vital for advancing our understanding of their biological significance and therapeutic potential in clinical settings.
