Analytical Data
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基因名
POLR1C
- Application
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别名
POLR1C;POLR1E;DNA-directed RNA polymerases I and III subunit RPAC1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15160
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表达区间
1-346aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGS MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD
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分子量
42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POLR1C, a critical component of RNA polymerase I, plays a vital role in the transcription of ribosomal RNA (rRNA), which is essential for ribosome biogenesis and consequently for cellular protein synthesis. Research on POLR1C has gained significant attention due to its involvement in various cellular processes and its implications in diseases, including cancer. Mutations or dysregulation of POLR1C can lead to defects in rRNA synthesis, resulting in impaired ribosome production and cellular growth, which highlights its importance in maintaining normal cellular functions. In recent years, studies have demonstrated that POLR1C is not only crucial for ribosomal RNA transcription but also participates in the regulation of other cellular pathways, making it a potential target for therapeutic interventions. Understanding the structural and functional properties of recombinant POLR1C is essential for elucidating its role in transcription regulation and its contribution to the pathogenesis of related diseases. This ongoing research holds promise for advancing knowledge regarding gene expression regulation and may inform the development of novel strategies for treating diseases linked to POLR1C dysfunction.
