Analytical Data
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Gene name
MLC1SA
- Application
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Alternative Names
MLC1sa; MYL 6B; Myl6b; MYL6B_HUMAN; Myosin alkali light chain 1 slow a; Myosin light chain 1 slow a; Myosin light chain 1 slow twitch muscle A isoform; Myosin light chain 1 slow-twitch muscle A isoform; Myosin light chain 6B alkali smooth muscle and non muscle; Myosin light chain 6B; Myosin light polypeptide 6B alkali smooth muscle and non muscle; Myosin light polypeptide 6B; Smooth muscle and non muscle myosin alkali light chain 6B; Smooth muscle and nonmuscle myosin light chain alkali 6B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14649
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Expression Region
1-208 aa
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AA Sequence
MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA FLKHILSV
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Molecular Weight
22.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLC1SA is a recombinant protein derived from the MLC1 gene, which is associated with various cellular functions including ion transport and cell signaling. This protein has attracted significant research interest due to its implications in certain neurodegenerative diseases and its role in maintaining cellular homeostasis. The MLC1 protein is primarily expressed in glial cells of the central nervous system, where it is thought to participate in the regulation of potassium ion transport and the maintenance of the blood-brain barrier. Mutations in the MLC1 gene are linked to diseases such as megalencephalic leukoencephalopathy with subcortical cysts (MLC), characterized by brain swelling and cyst formation. Understanding the structure and function of MLC1SA can provide insights into the pathogenic mechanisms underlying such disorders. Moreover, recombinant forms of MLC1SA are useful for biochemical assays and for developing potential therapeutic strategies aimed at restoring normal MLC1 function. The study of MLC1SA also contributes to the broader understanding of glial cell physiology and the role of ion transporters in neuronal health. Current research focuses on elucidating the protein's three-dimensional structure, its interaction with other cellular components, and the effects of specific mutations on its functionality. This knowledge could pave the way for innovative treatments targeting ion transport dysregulation in related neurological conditions.
