Analytical Data
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基因名
MKKS
- Application
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别名
Bardet Biedl syndrome 6 protein; Bardet-Biedl syndrome 6 protein; BBS6; HMCS; KMS; McKusick Kaufman syndrome; McKusick Kaufman/Bardet Biedl syndromes putative chaperonin; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Mkks; MKKS_HUMAN; MKS
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPJ1
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表达区间
1-570 aa
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氨基酸序列
MSRLEAKKPS LCKSEPLTTE RVRTTLSVLK RIVTSCYGPS GRLKQLHNGF GGYVCTTSQS SALLSHLLVT HPILKILTAS IQNHVSSFSD CGLFTAILCC NLIENVQRLG LTPTTVIRLN KHLLSLCISY LKSETCGCRI PVDFSSTQIL LCLVRSILTS KPACMLTRKE TEHVSALILR AFLLTIPENA EGHIILGKSL IVPLKGQRVI DSTVLPGILI EMSEVQLMRL LPIKKSTALK VALFCTTLSG DTSDTGEGTV VVSYGVSLEN AVLDQLLNLG RQLISDHVDL VLCQKVIHPS LKQFLNMHRI IAIDRIGVTL MEPLTKMTGT QPIGSLGSIC PNSYGSVKDV CTAKFGSKHF FHLIPNEATI CSLLLCNRND TAWDELKLTC QTALHVLQLT LKEPWALLGG GCTETHLAAY IRHKTHNDPE SILKDDECTQ TELQLIAEAF CSALESVVGS LEHDGGEILT DMKYGHLWSV QADSPCVANW PDLLSQCGCG LYNSQEELNW SFLRSTRRPF VPQSCLPHEA VGSASNLTLD CLTAKLSGLQ VAVETANLIL DLSYVIEDKN
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分子量
62.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MKKS (McKusick-Kaufman syndrome) protein, also known as BBS6, is a member of the chaperonin family, which plays a critical role in protein folding and assembly within the cell. Research on MKKS has garnered attention due to its association with McKusick-Kaufman syndrome, a rare genetic disorder characterized by multiple congenital anomalies, including hydrometrocolpos, polysyndactyly, and obesity, as well as its implications in Bardet-Biedl syndrome, which involves obesity, retinal degeneration, and kidney abnormalities. The MKKS protein is localized in the cytoplasm, functioning as a molecular chaperone that assists in the proper folding of various protein substrates, particularly in facilitating the formation of functional cilia and flagella. Dysfunction in MKKS is implicated in the disruption of these cellular structures, leading to the phenotypic manifestations observed in related syndromes. Thus, exploring the structure, function, and pathological roles of MKKS protein is essential for understanding the molecular mechanisms underlying these syndromes. This research not only provides insights into the fundamental biology of protein chaperones but also has potential implications for developing therapeutic strategies for managing the clinical features associated with MKKS and related disorders. Current studies focus on elucidating the interaction networks and cellular pathways influenced by MKKS, which may reveal novel targets for intervention and improve the understanding of ciliopathies and congenital syndromes linked to this protein.
