Analytical Data
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基因名
RTN1
- Application
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别名
RTN1；NSP；Reticulon-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16799
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表达区间
1-776aa
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氨基酸序列
MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
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分子量
83.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RTN1 (Reticulon 1) is a member of the reticulon family of proteins, which play crucial roles in maintaining cell morphology, particularly in the endoplasmic reticulum (ER) and neuronal function. Research into RTN1 has gained momentum due to its involvement in various cellular processes, including membrane dynamics, apoptosis, and neurodegenerative diseases. RTN1 is also implicated in the formation of tubular structures within the ER, contributing to cellular integrity and signaling pathways. Its expression pattern varies across tissues, with significant levels found in the nervous system, where it is thought to influence neuronal survival and plasticity. Additionally, RTN1 has been explored for its potential role in disease mechanisms such as Alzheimer's and amyotrophic lateral sclerosis (ALS), highlighting its importance in neurobiology. Recent studies have focused on the functional implications of RTN1 in cellular stress responses and its interactions with other cellular components, making it a candidate for further investigation in therapeutic strategies. Understanding RTN1's structure and function, particularly through the characterization of recombinant RTN1 proteins, is essential for elucidating its contribution to disease pathology and cellular health. Consequently, elucidating the biochemical properties and functional roles of RTN1 may provide valuable insights into its potential as a biomarker or therapeutic target for neurodegenerative diseases and other conditions associated with cellular stress responses.
