Analytical Data
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基因名
PMF1-BGLAP
- Application
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别名
;
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
U3KQ54
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表达区间
1-211aa
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氨基酸序列
MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQVQAQQQAWQVRSPAVQSPAKVQPLCPSRRAAR
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on the PMF1-BGLAP recombinant protein stems from the increasing interest in understanding the molecular mechanisms underlying bone metabolism and mineralization. PMF1 (Pseudomonas Methylmalonyl-CoA mutase Family 1) has been shown to play a crucial role in regulating osteoblast differentiation and function, while BGLAP (Bone Gla Protein) is a key player in bone mineralization and calcium homeostasis. The interaction between these two proteins could provide valuable insights into the pathways that govern bone health and development. Previous studies have indicated that dysregulation of osteogenic proteins can lead to various bone-related disorders, such as osteoporosis and fractures. Therefore, the production of a recombinant PMF1-BGLAP fusion protein enables researchers to explore the functional characteristics and potential therapeutic applications of these proteins in bone regeneration. Such studies are essential for advancing our knowledge of skeletal biology and for developing novel treatments to combat bone diseases. Through techniques like protein expression, purification, and functional assays, scientists aim to elucidate the interaction mechanisms of PMF1 and BGLAP, potentially leading to breakthroughs in regenerative medicine and the enhancement of bone repair strategies.
