Analytical Data
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Gene name
PLSCR3
- Application
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Alternative Names
PLSCR3;Phospholipid scramblase 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRY6
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Expression Region
1-265aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAGYLPP KGYAPSPPPP YPVTPGYPEP ALHPGPGQAP VPAQVPAPAP GFALFPSPGP VALGSAAPFL PLPGVPSGLE FLVQIDQILI HQKAERVETF LGWETCNRYE LRSGAGQPLG QAAEESNCCA RLCCGARRPL RVRLADPGDR EVLRLLRPLH CGCSCCPCGL QEMEVQAPPG TTIGHVLQTW HPFLPKFSIQ DADRQTVLRV VGPCWTCGCG TDTNFEVKTR DESRSVGRIS KQWGGLVREA LTDADDFGLQ FPLDLDVR
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Molecular Weight
31 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLSCR3, or phospholipid scramblase 3, is an integral membrane protein that plays a crucial role in cellular processes such as membrane dynamics, apoptosis, and immune responses. It is part of the scramblase family, which facilitates the bidirectional movement of phospholipids between the inner and outer leaflets of the plasma membrane, a process essential for various cellular functions, including blood coagulation and cellular signaling. Research into PLSCR3 has gained momentum due to its involvement in several pathological conditions, including cancer and autoimmune diseases, suggesting that it may serve as a potential therapeutic target. Additionally, PLSCR3's unique structural and functional properties have spurred interest in its potential applications in biotechnology and drug delivery systems. Understanding the mechanisms by which PLSCR3 operates, including its interactions with other cellular components and its regulatory pathways, is vital for harnessing its therapeutic potential and elucidating its role in health and disease. As the field of synthetic biology progresses, the engineering of PLSCR3 as a recombinant protein presents exciting opportunities for both basic research and clinical applications, particularly in developing novel strategies for manipulating cellular membranes and enhancing drug efficacy.
