Analytical Data
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Gene name
MAVS
- Application
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Alternative Names
MAVS；IPS1；KIAA1271；VISA；Mitochondrial antiviral-signaling Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z434
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Expression Region
1-513aa
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AA Sequence
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSP
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Molecular Weight
66.5kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAVS (mitochondrial antiviral signaling protein) is a crucial component of the innate immune response, playing a significant role in the detection of viral infections. It is primarily located on the outer mitochondrial membrane and is involved in the signaling cascade that activates the transcription of type I interferons and other pro-inflammatory cytokines in response to viral pathogens. The research surrounding MAVS recombinant proteins has emerged due to its pivotal involvement in immune signaling pathways, particularly in the context of RNA virus detection, such as those from the influenza or hepatitis C virus families. By studying MAVS, researchers aim to better understand its structure-function relationship and how mutations or modifications can affect its activity and interactions with other signaling molecules. Furthermore, MAVS has garnered attention for its potential role in therapeutic applications, as manipulating MAVS signaling pathways could enhance antiviral responses or mitigate autoimmune disorders linked to excessive interferon signaling. Advances in recombinant protein technology allow for the detailed study of MAVS, providing insights into developing novel strategies for vaccine design, antiviral therapies, and understanding the molecular mechanisms underlying host-pathogen interactions. Thus, research on MAVS recombinant proteins not only expands our knowledge of innate immunity but also presents avenues for innovative medical interventions against viral infections and related diseases.
