Analytical Data
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基因名
MICALCL
- Application
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别名
MICALCL; MICAL C-terminal-like protein; Mical-cL; ERK2-binding testicular protein 1; Ebitein-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZW33
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表达区间
1-695 aa
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氨基酸序列
MSPPKDPSPS LPLPSSSSHS SSPPSSSSTS VSGNAPDGSS PPQMTASEPL SQVSRGHPSP PTPNFRRRAV AQGAPREIPL YLPHHPKPEW AEYCLVSPGE DGLSDPAEMT SDECQPAEAP LGDIGSNHRD PHPIWGKDRS WTGQELSPLA GEDREKGSTG ARKEEEGGPV LVKEKLGLKK LVLTQEQKTM LLDWNDSIPE SVHLKAGERI SQKSAENGRG GRVLKPVRPL LLPRAAGEPL PTQRGAQEKM GTPAEQAQGE RNVPPPKSPL RLIANAIRRS LEPLLSNSEG GKKAWAKQES KTLPAQACTR SFSLRKTNSN KDGDQHSPGR NQSSAFSPPD PALRTHSLPN RPSKVFPALR SPPCSKIEDV PTLLEKVSLQ ENFPDASKPP KKRISLFSSL RLKDKSFESF LQESRQRKDI RDLFGSPKRK VLPEDSAQAL EKLLQPFKST SLRQAAPPPP PPPPPPPPPP TAGGADSKNF PLRAQVTEAS SSASSTSSSS ADEEFDPQLS LQLKEKKTLR RRKKLEKAMK QLVKQEELKR LYKAQAIQRQ LEEVEERQRA SEIQGVRLEK ALRGEADSGT QDEAQLLQEW FKLVLEKNKL MRYESELLIM AQELELEDHQ SRLEQKLREK MLKEESQKDE KDLNEEQEVF TELMQVIEQR DKLVDSLEEQ RIREKAEDQH FESFVFSRGC QLSRT
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分子量
219.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MICALCL, or MICAL C-terminal like, is a member of the MICAL family of proteins, which are known for their roles in regulating cytoskeletal dynamics and cellular processes. The study of MICALCL has gained momentum due to its potential involvement in various biological processes and disease mechanisms, particularly in the context of neurodevelopment and cancer. MICAL proteins are characterized by their ability to catalyze the oxidation of actin, leading to the destabilization of actin filaments and influencing cell morphology, motility, and differentiation. Recent research has highlighted the significance of MICALCL in mediating cell signaling pathways and its interaction with other proteins, such as signaling molecules and cytoskeletal components, suggesting its pivotal role in cellular homeostasis. Understanding the structure-function relationship of MICALCL through recombinant protein studies could provide insights into its biochemical properties and physiological functions. This research is crucial, as it may uncover new therapeutic targets for diseases where MICAL pathways are dysregulated, thereby enhancing our understanding of cellular mechanisms in health and disease. Overall, the elucidation of MICALCL’s role in cellular physiology represents a promising avenue for future studies in cell biology and therapeutic interventions.
